詳細資料

  • Evidence-Based Complementary and Alternative Medicine

Publication Date: year 2016

Evidence-Based Complementary and Alternative Medicine

Title of Article Title of Article：

Chinese Herbal Mixture, Tien-Hsien Liquid,Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.

Research author Research author：

Chih-Jung Yao,1,2,3

Jyh-Ming Chow,3,4

Chia-Ming Yang,5

Hui-Ching Kuo,2

Chia-Lun Chang,4

Hsin-Lun Lee,6

I-Chun Lai,7

Shuang-En Chuang,8

Gi-Ming Lai1,2,3,4,8

Research unit Research unit：

1Comprehensive Cancer Center, Taipei Medical University, Taipei 11031, Taiwan

2Cancer Center,Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan

3Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan

4Division of Hematology and Medical Oncology, Department of Internal Medicine,Wan Fang Hospital, Taipei Medical University,Taipei 11696, Taiwan

5Formosa Cancer Foundation, Taipei 10597, Taiwan

6The Ph.D. Program for Translational Medicine, Taipei Medical University-Academia Sinica, Taipei 11031, Taiwan

7Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei 11217, Taiwan

8National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan

Research unit Conclusions：

Our results demonstrate that THL induces G2/M cell cycle arrest and radiosensitization in MCF-7 cells. The main underlying mechanisms are proposed to involve tumor suppressor (p21 and p15) induction and DNA repair repression orchestrated by the downregulation of DNMT1. In order for the complete integration of THL into complementary cancer therapy regimens, a comprehensive and detailed investigation of its mechanisms of action is warranted, coupled with thorough efficacy assessments through clinical trials.

 

Journal Introduction Journal Introduction：

The Evidence-Based Complementary and Alternative Medicine was established in 2004 by Professor Edwin L. Cooper. It is a medical journal with an international prospective that mainly collects papers on complementary and alternative medicine and encourages exploring folk medicine and new therapies for further understanding and examination.

Impact Factor for 2011 is 4.774.

Link to Journal Link to Journal：

website address：http://www.hindawi.com

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