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Publication Date: April, 2005, Volume 11 Number 2

Title of Article：

The Chinese Herbal Medicine Tien-Hsien Liquid Inhibits Cell Growth and Induces Apoptosis in a Wide Variety of Human Cancer Cells.

Research author：

Dr.Sun Andy, Dr. Chia Jean-San, Dr. Wang Won-Bo, Dr. Chiang Chun Pin

Research unit：

Graduate Institute of Microbiology, National Taiwan University, College of Medicine
Dental Dept., National Taiwan University

 Conclusions：

In summary, our present study demonstrates that THL can induce apoptosis in a variety of human cancer cell lines but not in normal cells. THL treatment of H1299 cancer cells resulted in activation of caspase-8, -9 and -3, suggesting that THL may induce various apoptotic signals. These data together with our recent finding that THL has strong immunomodulatory effects (Sun el al., 2004) and other previous studies showing that constituent herbs of THL have antioxidant, immunomodulatory, antimutagenic, cytotoxic and cytostatic effects strongly suggest that THL is a promising cancer chemotherapeutic or chemopreventive agent. This assertion was also supported by our animal experiments that showed that THL had antitumor activities in mice (data not shown).

Journal Introduction：

The Journal of Alternative and Complementary Medicine was established in 1995. It primarily collects research papers on integrated medicine, natural medicine, any measure beneficial to treatment interest in order to assess and provide diverse fields of medical research compatible with or different from the analysis. Papers on clinical care, health policy formulation and coordination, and case reports favorable to overall medical science is also the focus of recent issues.

Impact Factor for 2011 is 1.585.

Link to Journal：

website address：http://online.liebertpub.com

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