Detailed material

Evidence-Based Complementary and Alternative Medicine

Publication Date: year 2012

Title of Article：

Elimination of Cancer Stem-Like “Side Population” Cells in Hepatoma Cell Lines by Chinese Herbal Mixture “Tien-Hsien Liquid”

Research author：

Chih-Jung Yao,1,2,3

Chi-Tai Yeh,2,4,5,6

Shuang-En Chuang,7

Chuan-Feng Yeh,7

Wan-Ju Chao,7

Tung-Yuan Lai,8,9

Gi-Ming Lai1,2,3,7

Research unit：

1Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan

2Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan

3Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan

4Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

5Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan

6Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

7National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan

8Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

9Department of Traditional Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Research unit Conclusions：

We investigated the effects of Chinese herbal mixture Tien-Hsien Liquid (THL) on cancer stem-like side population (SP) in hepatoma Huh7 cells. THL significantly reduced the viability, clonogenicity, and tumorigenicity of Huh7 SP cells. The underlying mechanisms of SP elimination were related to the inhibition on the expression of stemness genes such as ABCG2, CD133, SMO, and Gli. Moreover, combination with THL could synergize the effect of doxorubicin against Huh7 SP cells. Our data indicate that THL may act as a cancer stem cell targeting therapeutics and be regarded as complementary and integrative medicine for the treatment of hepatoma.

Journal Introduction：

The Evidence-Based Complementary and Alternative Medicine was established in 2004 by Professor Edwin L. Cooper. It is a medical journal with an international prospective that mainly collects papers on complementary and alternative medicine and encourages exploring folk medicine and new therapies for further understanding and examination.

Impact Factor for 2011 is 4.774.

Link to Journal：

website address：http://www.hindawi.com

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